Procoagulant Platelets

Procoagulant Platelets

Procoagulant platelets are known by several synonyms, including collagen and thrombin–activated platelets, coated platelets, sustained calcium–induced platelet morphology, superactivated platelets, and superplatelets. This assortment of names is confusing to those outside the field and has remained a stubborn problem within the field. However, it is key to recognize that all of these variously ...

Procoagulant Activity of Adherent Platelets

........................................................................................................................ 9 INTRODUCTION ............................................................................................................... 11 REVIEW OF THE LITERATURE ...................................................................................... 13 1. Platelets .....................

Procoagulant Activity of Adherent Platelets

The possibility that platelets release microvesicles on adherence to either von Willebrand factor (vWf) or collagen was examined by flow cytometry analysis of the supernatant above layers of adherent platelets. No microvesicle release was detected as a result of adherence to vWf or to collagen, a known platelet agonist. Approximately 8% of the total platelet mass was released as microvesicles a...

Procoagulant platelets: are they necrotic?

Apoptosis and necrosis represent distinct cell death processes that regulate mammalian development, physiology and disease. Apoptosis characteristically leads to the silent destruction and removal of cells in the absence of an inflammatory response. In contrast, necrotic cell death can induce physiologic inflammatory responses linked to tissue defense and repair. Although anucleate, platelets u...

Procoagulant Platelets: Not Just Full of Hot Air Running title: Battinelli; Procoagulant Platelets: Not just full of hot air